NS 3861

NS 3861 is a neuronal nicotinic acetylcholine receptor (nAChR) agonist. It induces inward currents in patch-clamp assays using X. laevis oocytes expressing recombinant human alpha3beta2- or alpha3beta4 subunit-containing nAChR receptors (EC50s = 1.6 and 1 µM, respectively). In vivo, NS 3861 (0.1 mg/kg) increases the number of fecal pellets expelled in mice exposed to long-term, but not short-term, morphine injections.Formal Name: 3-(3-bromo-2-thienyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene. CAS Number: 216853-59-7. Molecular Formula: C12H14BrNS. Formula Weight: 284.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. SMILES: CN1C2CC(C3=C(Br)C=CS3)=CC1CC2. InChi Code: InChI=1S/C12H14BrNS/c1-14-9-2-3-10(14)7-8(6-9)12-11(13)4-5-15-12/h4-6,9-10H,2-3,7H2,1H3. InChi Key: ZJCNRVHZJADROC-UHFFFAOYSA-N.