NS 309

NS 309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activate voltage-gated Kv11.1 channels (hERG, IC50 = 1 µM), but does not, however, affect large conductance (BK/KCa1.1) channels. NS 309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects. It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO (Cay-14575) and often used in conjunction with CyPPA (Cay-15614) to distinguish between SK1 and SK3 subtypes.Formal Name: 6,7-dichloro-1H-indole-2,3-dione 3-oxime. CAS Number: 18711-16-5. Molecular Formula: C8H4Cl2N2O2. Formula Weight: 231.0. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 233, 262, 313, 347 nm. SMILES: O=C1/C(C2=CC=C(Cl)C(Cl)=C2N1)=N\O. InChi Code: InChI=1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,14H,(H,11,12,13). InChi Key: CVOUSAVHMDXCKG-UHFFFAOYSA-N.