NS 13001

NS 13001 is a positive allosteric modulator for small-conductance calcium-activated potassium channel 2 (KCa2.2/SK2) and KCa2.3/SK3. It increases calcium-induced currents in an inside-out patch clamp assay using HEK293 cells expressing human KCa2.2/SK2 or KCa2.3/SK3 (EC50s = 1.8 and 0.14 µM, respectively). Oral administration of NS 13001 (30 mg/kg per day) improves sensorimotor deficits in the beam walk test and increases the latency to fall in the rotarod test in a SCA2-58Q transgenic mouse model of neuromuscular degeneration.Formal Name: N-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine. CAS Number: 1063331-94-1. Molecular Formula: C17H16ClN7. Formula Weight: 353.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 0.5 mg/ml, PBS (pH 7.2): 0.3 mg/ml. lambdamax: 269, 303 nm. SMILES: ClC1=CC=C(C=C1)NC2=C(C3=NC(N4N=C(C=C4C)C)=N2)N=CN3C. InChi Code: InChI=1S/C17H16ClN7/c1-10-8-11(2)25(23-10)17-21-15(14-16(22-17)24(3)9-19-14)20-13-6-4-12(18)5-7-13/h4-9H,1-3H3,(H,20,21,22). InChi Key: DVQOPNIPUIOXHU-UHFFFAOYSA-N.