Novobiocin (sodium salt)

Bacterial DNA gyrase is a heterodimeric type II topoisomerase that negatively supercoils circular double-stranded DNA. Novobiocin is a coumarin antibiotic, first isolated from Streptomyces species, that inhibits the ATPase activity of DNA gyrase. Its antibacterial activity arises from competitive inhibition of the ATPase reaction catalyzed by the GyrB subunit. In addition to permitting relaxation of negative supercoils, novobiocin has been used to generate positively supercoiled DNA. It also inhibits the chaperone activity of Hsp90 (IC50 = 700 mM).Formal Name: N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-alpha-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-benzamide, monosodium salt. CAS Number: 1476-53-5. Synonyms: NSC 2382. Molecular Formula: C31H35N2O11 . Na. Formula Weight: 634.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: 100 mg/ml. lambdamax: 212, 249, 307 nm. SMILES: O[C@H]1[C@H](OC2=CC=C(C(O)=C(NC(C3=CC(C/C=C(C)\C)=C([O-])C=C3)=O)C(O4)=O)C4=C2C)OC(C)(C)[C@H](OC)[C@H]1OC(N)=O.[Na+]. InChi Code: InChI=1S/C31H36N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29,/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37),/q,+1/p-1/t23-,25+,26-,29-,/m1./. InChi Key: WWPRGAYLRGSOSU-RNROJPEYSA-M.