NOS-IN-1

Description: NOS-IN-1 (2-Imino-4-methylpiperidine acetate) is a potent and orally active inhibitor of NO synthase (NOS) isoforms. NOS-IN-1 exhibits IC50s of 0.1 µM, 0.2 µM, and 1.1µM for human iNOS (hiNOS), hnNOS and heNOS, respectively. Target: NOS. Smiles: CC(CCN1)CC1=N.CC(O)=O. References: R K Webber, et al. Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1998 Jan 1,41(1):96-101.