Normetanephrine (hydrochloride)

Normetanephrine is an active metabolite of norepinephrine. It is formed from norepinephrine by catechol-O-methyltransferase (COMT). Normetanephrine induces contractions in isolated rabbit aortic strips in a concentration-dependent manner. It inhibits norepinephrine uptake in isolated rat heart (IC50 = 200 µM). Plasma levels of normetanephrine are increased in patients with von Hippel-Lindau disease and pheochromocytomas compared with patients with von Hippel-Lindau disease without pheochromocytomas. It has been used as a marker of authentic human urine specimens.Formal Name: alpha-(aminomethyl)-4-hydroxy-3-methoxy-benzenemethanol, monohydrochloride. CAS Number: 1011-74-1. Synonyms: DL-Normetanephrine, (±)-Normetadrenaline, NMN, alpha-(aminomethyl)Vanillyl Alcohol. Molecular Formula: C9H13NO3 . HCl. Formula Weight: 219.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble, DMSO: Soluble, Water: Slightly soluble. SMILES: OC1=CC=C(C(CN)O)C=C1OC.Cl. InChi Code: InChI=1S/C9H13NO3.ClH/c1-13-9-4-6(8(12)5-10)2-3-7(9)11,/h2-4,8,11-12H,5,10H2,1H3,1H. InChi Key: VKFPRGQZWKTEON-UHFFFAOYSA-N.