Norfluoxetine (hydrochloride)

Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A. Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15 nM). It has been found in the tissues of fish exposed to wastewater effluent.Formal Name: gamma-[4-(trifluoromethyl)phenoxy]-benzenepropanamine, monohydrochloride. CAS Number: 57226-68-3. Synonyms: Desmethylfluoxetine. Molecular Formula: C16H16F3NO . HCl. Formula Weight: 331.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 227, 264, 276 nm. SMILES: NCCC(C1=CC=CC=C1)OC2=CC=C(C(F)(F)F)C=C2.Cl. InChi Code: InChI=1S/C16H16F3NO.ClH/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12,/h1-9,15H,10-11,20H2,1H. InChi Key: GMTWWEPBGGXBTO-UHFFFAOYSA-N.