Nolatrexed dihydrochloride
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Nolatrexed dihydrochloride (Thymitaq) is the dihydrochloride salt of nolatrexed, a... more
Product information "Nolatrexed dihydrochloride"
Description: Nolatrexed dihydrochloride (Thymitaq) is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity. Target: DNA/RNA Synthesis. Smiles: Cl.Cl.Cc1ccc2[nH]c(N)nc(=O)c2c1Sc1ccncc1. References: Hughes AN, et al. Br J Y. 2000 May,82(9):1519-27.
| Keywords: | Thymitaq, AG 337 |
| Supplier: | TargetMol |
| Supplier-Nr: | T2627 |
Properties
| Application: | Thymidylate synthase inhibitor |
| MW: | 357.26 D |
| Formula: | C14H14Cl2N4OS |
Database Information
| CAS : | 152946-68-4| Matching products |
| KEGG ID : | K00560 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H341, H361 |
| P Phrases: | P201, P202, P280, P308+313, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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