Nocodazole

Nocodazole is an antimitotic agent. It increases tubulin GTP hydrolysis four-fold and induces tubulin depolymerization. Nocodazole (4 µg/ml) halts the cell cycle in the mitotic phase and synchronizes WI38 cells in the G2/M phase. It also decreases neuronal mitochondrial transport and density in a transgenic zebrafish model with neurons expressing fluorescent proteins in mitochondrial and cell membranes when used at a concentration of 400 nM.Formal Name: N-[6-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamic acid, methyl ester. CAS Number: 31430-18-9. Synonyms: NSC 238159, Oncodazole, R 17934. Molecular Formula: C14H11N3O3S. Formula Weight: 301.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 5 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 214, 258, 315 nm. SMILES: O=C(C1=CC=CS1)C2=CC(N=C(NC(OC)=O)N3)=C3C=C2. InChi Code: InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19). InChi Key: KYRVNWMVYQXFEU-UHFFFAOYSA-N.