NNGH

NNGH is a cell-permeable, broad-spectrum inhibitor of matrix metalloproteinases (MMPs). It blocks the activity of MMP-8, -9, -12, -13, and -20 with Ki values of 9, 2.6, 4.3, 3.1, and 17 nM, respectively. It also inhibits MMP-1, -3, -7, and -10 with Ki values of 0.17, 0.13, 13, and 0.1 µM, respectively. It is commonly used to study the role of MMP-3 (stromelysin 1) in biological systems.Formal Name: N-hydroxy-2-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-acetamide. CAS Number: 161314-17-6. Synonyms: N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl Hydroxamic Acid, Matrix Metalloproteinase-3 Inhibitor II, MMP-3 Inhibitor II. Molecular Formula: C13H20N2O5S. Formula Weight: 316.4. Purity: >99%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM, Ethanol: 25 mM. SMILES: ONC(CN(S(C1=CC=C(OC)C=C1)(=O)=O)CC(C)C)=O. InChi Code: InChI=1S/C13H20N2O5S/c1-10(2)8-15(9-13(16)14-17)21(18,19)12-6-4-11(20-3)5-7-12/h4-7,10,17H,8-9H2,1-3H3,(H,14,16). InChi Key: JIRXORZYIXSWOB-UHFFFAOYSA-N.