Nitrofurazone

Nitrofurazone is a nitrofuran antibiotic that is active against a variety of Gram-negative and Gram-positive bacteria including laboratory strains of S. aureus, E. faecalis, and E. coli (MICs = 8 µg/ml for all) as well as clinical isolates of several urinary tract pathogens including Enterococcus, coagulase-negative staphylococci, Klebsiella, and P. mirabilis (MICs = 2-64 µg/ml). Nitrofurazone induces mutagenicity in mammalian and bacterial cell-based assays and carcinogenesis, reproductive effects, and toxicity in rats and mice (LD50s = 590 and 640 mg/kg, respectively). Formulations containing nitrofurazone have been used in the topical treatment and prevention of bacterial infections in humans and animals as well as oral treatment of trypanosomiasis.Formal Name: 2-[(5-nitro-2-furanyl)methylene]-hydrazinecarboxamide. CAS Number: 59-87-0. Synonyms: Furacilin, Nitrofural, NSC 1602, NSC 2100, NSC 44009. Molecular Formula: C6H6N4O4. Formula Weight: 198.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 264, 367 nm. SMILES: NC(N/N=C/C1=CC=C([N+]([O-])=O)O1)=O. InChi Code: InChI=1S/C6H6N4O4/c7-6(11)9-8-3-4-1-2-5(14-4)10(12)13/h1-3H,(H3,7,9,11)/b8-3+. InChi Key: IAIWVQXQOWNYOU-FPYGCLRLSA-N.