Nitrendipine

Nitrendipine is a dihydropyridine used as an antihypertensive agent due to its ability to block L-type and T-type calcium channels, which play key roles in excitation-contraction coupling in cardiac and vascular smooth muscle cells, producing vasodilatory actions. It also binds to adenosine A1, A2A, and A3 receptors with Ki values of 8.96, 23.0, and 8.3 µM, respectively.Formal Name: 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-ethyl 5-methyl ester. CAS Number: 39562-70-4. Molecular Formula: C18H20N2O6. Formula Weight: 360.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 25 mg/ml, Ethanol: 2 mg/ml. lambdamax: 236, 353 nm. SMILES: CC1=C(C(C(C(OCC)=O)=C(N1)C)C2=CC([N+]([O-])=O)=CC=C2)C(OC)=O. InChi Code: InChI=1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3. InChi Key: PVHUJELLJLJGLN-UHFFFAOYSA-N.