Nisin (>900 IU/mg, contains min. 50% NaCl)

Nisin A is a bacteriocin, a natural polycyclic antibacterial peptide. It is produced by the lactic acid bacterium L. lactis using uncommon amino acids, including lanthionine, and is a member of the class of antibiotics referred to as lantibiotics. Nisin A is particularly effective against Gram-positive bacteria and is commonly used as a food preservative. Lantibiotics, including nisin A, form complexes with membrane-bound peptidoglycan precursors on the surface of bacteria, resulting in pore formation and cell death.Formal Name: L-isoleucyl-(Z)-2,3-didehydro-2-aminobutanoyl-D-cysteinyl-L- isoleucyl-2,3-didehydroalanyl-L-leucyl-L-cysteinyl-threo-3- mercapto-D-2-aminobutanoyl-L-prolylglycyl-L-cysteinyl-L-lysyl- threo-3-mercapto-D-2-aminobutanoylglycyl-L-alanyl-L-leucyl-L- methionylglycyl-L-cysteinyl-L-asparaginyl-L-methionyl-L-lysyl- threo-3-mercapto-D-2-aminobutanoyl-L-alanyl-threo-3-mercapto- D-2-aminobutanoyl-L-cysteinyl-L-histidyl-L-cysteinyl-L-seryl- L-isoleucyl-L-histidyl-L-valyl-2,3-didehydroalanyl- L-lysine, cyclic (3->7),(8->11),(13->19),(23->26),(25->28)-pentakis(sulfide). CAS Number: 1414-45-5. Synonyms: Ambicin N. Molecular Formula: C143H230N42O37S7. Formula Weight: 3354.1. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.25 mg/ml, PBS (pH 7.2): 0.5 mg/ml. Specific Activity: 1126 IU/mg. SMILES: O=C(N1[C@@]([H])(CCC1)C(NC2)=O)[C@@H](NC([C@@H](NC([C@H](CC(C)C)NC(C(N3)=C)=O)=O)CSC[C@@H](NC(/C(NC([C@H]([C@H](CC)C)N)=O)=C/C)=O)C(N[C@]([H])(C3=O)[C@H](CC)C)=O)=O)[C@H](C)SC[C@@H](C(N[C@H](C(N[C@@H]([C@H](C)SC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]([C@H](C)SC[C@@]([H])(C(N[C@]4(CC5=CN=CN5)[H])=O)NC6=O)C(N[C@@]([H])(C)C(N[C@@]6([C@]([H])(C)SC[C@H](NC4=O)C(N[C@H](C(N[C@]([H])(C(N[C@@H](CC7=CN=CN7)C(N[C@H](C(NC(C(N[C@@H](CCCCN)C(O)=O)=O)=C)=O)C(C)C)=O)=O)[C@H](CC)C)=O)CO)=O)[H])=O)=O)=O)CCCCN)=O)CCSC)=O)CC(N)=O)=O)NC(CNC([C@H](CCSC)N8)=O)=O)C(NCC(N[C@@H](C)C(N[C@H](CC(C)C)C8=O)=O)=O)=O)=O)CCCCN)=O)NC2=O. InChi Code: InChI=1S/C143H230N42O37S7/c1-24-69(11)105(148)135(213)162-82(27-4)118(196)174-94-58-225-59-95(175-123(201)89(48-67(7)8)169-115(193)74(16)158-138(216)107(70(12)25-2)180-132(94)210)133(211)184-112-79(21)229-61-96(160-104(190)56-152-134(212)100-38-34-44-185(100)142(112)220)128(206)164-84(36-29-32-42-145)120(198)182-109-76(18)226-60-97(161-103(189)55-151-117(195)85(39-45-223-22)165-122(200)88(47-66(5)6)168-113(191)72(14)156-102(188)54-153-136(109)214)129(207)171-92(51-101(147)187)125(203)166-86(40-46-224-23)119(197)163-83(35-28-31-41-144)121(199)183-110-77(19)228-63-99-130(208)170-90(49-80-52-149-64-154-80)124(202)176-98(62-227-78(20)111(141(219)177-99)181-116(194)75(17)159-140(110)218)131(209)173-93(57-186)127(205)179-108(71(13)26-3)139(217)172-91(50-81-53-150-65-155-81)126(204)178-106(68(9)10)137(215)157-73(15)114(192)167-87(143(221)222)37-30-33-43-146/h27,52-53,64-72,75-79,83-100,105-112,186H,15-16,24-26,28-51,54-63,144-146,148H2,1-14,17-23H3,(H2,147,187)(H,149,154)(H,150,155)(H,151,195)(H,152,212)(H,153,214)(H,156,188)(H,157,215)(H,158,216)(H,159,218)(H,160,190)(H,161,189)(H,162,213)(H,163,197)(H,164,206)(H,165,200)(H,166,203)(H,167,192)(H,168,191)(H,169,193)(H,170,208)(H,171,207)(H,172,217)(H,173,209)(H,174,196)(H,175,201)(H,176,202)(H,177,219)(H,178,204)(H,179,205)(H,180,210)(H,181,194)(H,182,198)(H,183,199)(H,184,211)(H,221,222)/b82-27-/t69-,70-,71-,72-,75-,76-,77-,78-,79-,83-,84-,85-,86-,87-,88+,89-,90-,91-,92-,93-,94+,95-,96-,97-,98-,99-,100-,105-,106-,107-,108-,109-,110+,111+,112-/m0/s1. InChi Key: NVNLLIYOARQCIX-IYPQCFSLSA-N.