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![Nifuroxazide-d4](https://www.biomol.com/media/image/82/08/0d/Cay33382-1_600x600.png)
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Nifuroxazide-d4 is intended for use as an internal standard for the quantification of... more
Product information "Nifuroxazide-d4"
Nifuroxazide-d4 is intended for use as an internal standard for the quantification of nifuroxazide (Cay-18163) by GC- or LC-MS. Nifuroxazide is a nitrofuran antibiotic. It is active against strains of the enteropathogenic bacteria C. jejuni, Salmonella, Y. enterocolitica, Shigella, and E. coli. It inhibits quorum sensing and virulence factor production in P. aeruginosa. Nifuroxazide inhibits STAT3 activity in a reporter assay (IC50 = ~3 µM) and decreases viability of U266 and INA-6 myeloma cells, which have constitutive STAT3 phosphorylation, with EC50 values of approximately 4.5 µM for both. It also decreases viability, migration, and invasion of, and induces apoptosis in, MCF-7, 4T1, and MDA-MB-231 breast cancer cells. Nifuroxazide (50 mg/kg per day) reduces tumor growth and prevents pulmonary metastasis in a 4T1 murine mammary carcinoma model. It also reduces diarrhea, weight loss, and colon inflammation in a rat model of acetic acid-induced ulcerative colitis.Formal Name: 4-hydroxy-benzoic acid, 2-[(5-nitro-2-furanyl)methylene-d4]hydrazide. CAS Number: 1188487-83-3. Molecular Formula: C12H5D4N3O5. Formula Weight: 279.2. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble. SMILES: O=C(C1=C([2H])C([2H])=C(C([2H])=C1[2H])O)NN=CC2=CC=C([N+]([O-])=O)O2. InChi Code: InChI=1S/C12H9N3O5/c16-9-3-1-8(2-4-9)12(17)14-13-7-10-5-6-11(20-10)15(18)19/h1-7,16H,(H,14,17)/i1D,2D,3D,4D. InChi Key: YCWSUKQGVSGXJO-RHQRLBAQSA-N.
Keywords: | 4-hydroxy-benzoic acid, 2-[(5-nitro-2-furanyl)methylene-d4]hydrazide |
Supplier: | Cayman Chemical |
Supplier-Nr: | 33382 |
Properties
Application: | GC-MS, LC-MS, Internal standard, Quantification, Antibacterial antibiotic |
MW: | 279.2 D |
Formula: | C12H5D4N3O5 |
Purity: | >99% deuterated forms (d1-d4) |
Format: | Solid |
Database Information
CAS : | 1188487-83-3| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H302, H312, H315, H319, H332 |
P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P361+364, P362+364, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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