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![Nifedipine](https://www.biomol.com/media/image/02/3e/e4/Cay11106-1_600x600.png)
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Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of... more
Product information "Nifedipine"
Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 µM. Nifedipine (1 µM) reduces TGF-beta-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse model of pulmonary fibrosis induced by bleomycin (Cay-13877) when administered at a dose of 10 mg/kg per day. It also reduces increases in mean arterial blood pressure induced by angiotensin II (Cay-17150) in spontaneously hypertensive rats when administered at a dose of 10 µg/kg. Formulations containing nifedipine have been used in the treatment of hypertension and angina.Formal Name: 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3,5-dimethyl ester. CAS Number: 21829-25-4. Synonyms: BAY 1040. Molecular Formula: C17H18N2O6. Formula Weight: 346.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml, Ethanol: 1 mg/ml. lambdamax: 236, 334, 360 nm. SMILES: CC1=C(C(OC)=O)C(C(C(OC)=O)=C(C)N1)C2=CC=CC=C2[N+]([O-])=O. InChi Code: InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3. InChi Key: HYIMSNHJOBLJNT-UHFFFAOYSA-N.
Keywords: | BAY 1040, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3,5-dimethyl ester |
Supplier: | Cayman Chemical |
Supplier-Nr: | 11106 |
Properties
Application: | Dihydropyridine calcium channel blocker |
MW: | 346.3 D |
Formula: | C17H18N2O6 |
Purity: | >98% |
Format: | Crystalline Solid |
Database Information
CAS : | 21829-25-4| Matching products |
KEGG ID : | K04850 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H302, H361 |
P Phrases: | P201, P202, P264, P270, P280, P330, P301+P310, P308+P313, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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