(±)-Nicotine-d3

(±)-Nicotine-d3 is intended for use as an internal standard for the quantification of (±)-nicotine (Cay-16535) by GC- or LC-MS. (±)-Nicotine is the racemic mixture of the dominant alkaloid found in tobacco plants. It acts as an agonist at neuronal nicotinic acetylcholine receptors (nAChRs, Kis = 481 and 11.1 nM for alpha3beta4 and alpha4beta2 subtypes, respectively) and possesses addictive and teratogenic properties. (-)-(S)-Nicotine is significantly more active at binding nAChRs compared to the (+)-(R) antipode, thus nicotine is typically synthesized as (-)-(S)-nicotine with only 0.2-1% of the (+)-(R) isomer present.Formal Name: 3-[1-(methyl-d3)-2-pyrrolidinyl]-pyridine. CAS Number: 69980-24-1. Synonyms: DL-Nicotine-d3, (±)-Nicotine-methyl-d3. Molecular Formula: C10H11D3N2. Formula Weight: 165.3. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 50 mg/ml, DMSO: 30 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 262 nm. SMILES: [2H]C([2H])([2H])N1CCCC1C2=CC=CN=C2. InChi Code: InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/i1D3. InChi Key: SNICXCGAKADSCV-FIBGUPNXSA-N.