NIBR-0213

Description: NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis. Target: LPL Receptor. Smiles: CC=1C=C(C=C(C)C1C(N[C@H](C(O)=O)C)=O)C2=CC(N[C@H](C)C3=CC(C)=C(Cl)C=C3)=CC=C2. References: Bigaud M, Dincer Z, Bollbuck B, Dawson J, Beckmann N, Beerli C, Fishli-Cavelti G, Nahler M, Angst D, Janser P, Otto H, Rosner E, Hersperger R, Bruns C, Quancard J. Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism. PLoS One. 2016 Dec 22,11(12):e0168252. doi: 10.1371/journal.pone.0168252. eCollection 2016. PubMed PMID: 28005953, PubMed Central PMCID: PMC5179015.