NG,NG-dimethyl-L-Arginine

NG,NG-dimethyl-L-arginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS). It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2). ADMA levels are increased concomitant with an increase in blood pressure in Dahl salt-sensitive rats fed a high-salt diet. ADMA levels are increased in the plasma in a variety of endothelial dysfunction-related diseases, including hypertension, congestive heart failure, and end-stage renal disease.Formal Name: N5-[(dimethylamino)iminomethyl]-L-ornithine. CAS Number: 30315-93-6. Synonyms: ADMA, Asymmetric dimethylarginine. Molecular Formula: C8H18N4O2. Formula Weight: 202.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 3 mg/ml, Ethanol: 3 mg/ml, PBS (pH 7.2): freely soluble. lambdamax: 224 nm. SMILES: CN(C)C(NCCC[C@H](N)C(O)=O)=N. InChi Code: InChI=1S/C8H18N4O2/c1-12(2)8(10)11-5-3-4-6(9)7(13)14/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14)/t6-/m0/s1. InChi Key: YDGMGEXADBMOMJ-LURJTMIESA-N.