Neridronic Acid

Neridronic acid is an amino bisphosphonate that inhibits farnesyl pyrophosphate (FPP) synthase (IC50 = 388.2 nM in a cell-free assay). It decreases the differentiation of RAW 264.7 cells into osteoclasts in a CRL-12257 co-culture model of osteoclastogenesis when used at concentrations ranging from 0.001 to 100 µM. Neridronic acid (30 µM) inhibits FGF2-induced proliferation and tube formation in human umbilical vein endothelial cells (HUVECs). It reduces the loss of trabeculae and increases bone density in the tibial metaphysis of growing rats when administered subcutaneously at a dose of 0.1 mg/kg per day.Formal Name: P,P'-(6-amino-1-hydroxyhexylidene)bis-phosphonic acid. CAS Number: 79778-41-9. Synonyms: Neridronate. Molecular Formula: C6H17NO7P2. Formula Weight: 277.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. SMILES: NCCCCCC(O)(P(O)(O)=O)P(O)(O)=O. InChi Code: InChI=1S/C6H17NO7P2/c7-5-3-1-2-4-6(8,15(9,10)11)16(12,13)14/h8H,1-5,7H2,(H2,9,10,11)(H2,12,13,14). InChi Key: PUUSSSIBPPTKTP-UHFFFAOYSA-N.