Neostigmine (methyl sulfate)

Neostigmine is a reversible inhibitor of acetylcholinesterase (AChE, Kd = 260 µM). In a rat model of knee joint inflammation, intrathecal administration of neostigmine (2-30 µg) increases endogenous acetylcholine levels and dose-dependently increases the latency of paw withdrawal in response to thermal and mechanical stimuli (ED50s = 6.6 and 3.5 µg, respectively). Neostigmine (5 µg, i.p.) restores muscle action potentials in mice with a thymopoietin-induced neuromuscular block. Formulations containing neostigmine have been used in the treatment of myasthenia gravis and Ogilvie syndrome.Formal Name: 3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-benzenaminium, methyl sulfate. CAS Number: 51-60-5. Synonyms: NSC 93753. Molecular Formula: C12H19N2O2 . CH3SO4. Formula Weight: 334.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: **soluble, Water: *soluble. SMILES: C[N+](C)(C)C1=CC=CC(OC(N(C)C)=O)=C1.[O-]S(=O)(OC)=O. InChi Code: InChI=1S/C12H19N2O2.CH4O4S/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5,1-5-6(2,3)4/h6-9H,1-5H3,1H3,(H,2,3,4)/q+1,/p-1. InChi Key: OSZNNLWOYWAHSS-UHFFFAOYSA-M.