Neoline

Description: Neoline is an active ingredient of A. venetum root (PA) that ameliorates oxaliplatin-induced peripheral neuropathy in mice.Neoline inhibits Nav1.7 voltage-gated sodium channel currents (VGSC). It can be used as a labeling compound to determine the quality of PA products used in the study of neuropathic pain. Target: Others, Sodium Channel. Smiles: [H][C@]12C[C@]3([H])[C@]([H])([C@H]1O)[C@](O)(C[C@@H]2OC)[C@@]1([H])[C@H](OC)[C@@]2([H])C33[C@@H](O)CC[C@@]2(COC)CN(CC)[C@]13[H]. References: Suzuki, T., Miyamoto, K., Yokoyama, N., Sugi, M., Kagioka, A., & Kitao, Y. et al. (2016). Processed aconite root and its active ingredient neoline may alleviate oxaliplatin-induced peripheral neuropathic pain. Journal Of Ethnopharmacology, 186, 44-52. doi: 10.1016/j.jep.2016.03.056