Nemadipine A

Nemadipine A
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay21689-5 5 mg -

6 - 10 business days*

92.00€
Cay21689-10 10 mg -

6 - 10 business days*

175.00€
Cay21689-25 25 mg -

6 - 10 business days*

405.00€
Cay21689-50 50 mg -

6 - 10 business days*

764.00€
 
Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects... more
Product information "Nemadipine A"
Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel alpha1-subunit in the C. elegans genome. It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells. It also decreases Survivin expression when used alone or in combination with TRAIL in A549 cells.Formal Name: 1,4-dihydro-2,6-dimethyl-4-(2,3,4,5,6-pentafluorophenyl)-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester. CAS Number: 54280-71-6. Molecular Formula: C19H18F5NO4. Formula Weight: 419.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 20 mg/ml, Ethanol: 15 mg/ml, Methanol: 100 mg/ml. lambdamax: 231, 365 nm. SMILES: CC1=C(C(OCC)=O)C(C2=C(F)C(F)=C(F)C(F)=C2F)C(C(OCC)=O)=C(C)N1. InChi Code: InChI=1S/C19H18F5NO4/c1-5-28-18(26)9-7(3)25-8(4)10(19(27)29-6-2)11(9)12-13(20)15(22)17(24)16(23)14(12)21/h11,25H,5-6H2,1-4H3. InChi Key: QABNLWXKUCMDBP-UHFFFAOYSA-N.
Keywords: 1,4-dihydro-2,6-dimethyl-4-(2,3,4,5,6-pentafluorophenyl)-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester
Supplier: Cayman Chemical
Supplier-Nr: 21689

Properties

Application: Cell-permeable L-type calcium channel protein inhibitor
MW: 419.3 D
Formula: C19H18F5NO4
Purity: >98%

Database Information

CAS : 54280-71-6| Matching products
KEGG ID : K04853 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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