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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| Cay40465-500 | 500 µg | - |
6 - 10 business days* |
88.00€
|
|||
| Cay40465-1 | 1 mg | - |
6 - 10 business days* |
167.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Nedometinib is a MEK1 inhibitor (IC50 = 135 nM). It is selective for MEK1 over a panel of 44... more
Product information "Nedometinib"
Nedometinib is a MEK1 inhibitor (IC50 = 135 nM). It is selective for MEK1 over a panel of 44 receptors, ion channels, and enzymes at 10 µM, as well as a panel of an additional 150 kinases. Nedometinib (0.1-10 µM) decreases phosphorylation of ERK in malignant peripheral nerve sheath tumor cells. Topical application of nedometinib (0.1-2.3%) reduces the total number of tumors in a mouse model of cutaneous squamous cell carcinoma induced by UV radiation.Formal Name: 2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide. CAS Number: 2252314-46-6. Synonyms: NFX-179. Molecular Formula: C17H16FIN4O3. Formula Weight: 470.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: O=C(C(C1=CC=CN=C1N2C)=C2NC(C=CC(I)=C3)=C3F)NOCCO. InChi Code: InChI=1S/C17H16FIN4O3/c1-23-15-11(3-2-6-20-15)14(17(25)22-26-8-7-24)16(23)21-13-5-4-10(19)9-12(13)18/h2-6,9,21,24H,7-8H2,1H3,(H,22,25). InChi Key: SENAOZROGSYRTD-UHFFFAOYSA-N.
| Keywords: | NFX-179, 2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 40465 |
Properties
| Application: | MEK1 inhibitor |
| MW: | 470.2 D |
| Formula: | C17H16FIN4O3 |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 2252314-46-6| Matching products |
| KEGG ID : | K04368 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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