Nedocromil (sodium salt)

Nedocromil is a mast cell stabilizer. It inhibits IgE-induced histamine release from rat peritoneal mast cells cocultured with 3T3 cells (MC/3T3) and preincubated with IL-2 when used at a concentration of 10 µM in acute (1 hour) and chronic (5 days) assays. Nedocromil prevents early- and late-phase bronchoconstriction in a guinea pig model of asthma induced by ovalbumin. It also prevents conjunctival edema and erythema and reduces mast cell degranulation in a rat model of conjunctivitis when administered intravenously at a dose of 2 mg/kg. Formulations containing nedocromil have been used in the treatment of allergic conjunctivitis and asthma.Formal Name: 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, disodium salt. CAS Number: 69049-74-7. Molecular Formula: C19H15NO7 . 2Na. Formula Weight: 415.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 20 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 251, 286, 339, 372 nm. SMILES: O=C(C=C(C([O-])=O)O1)C(C1=C2CCC)=CC3=C2N(CC)C(C([O-])=O)=CC3=O.[Na+].[Na+]. InChi Code: InChI=1S/C19H17NO7.2Na/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11,,/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26),,/q,2*+1/p-2. InChi Key: JQEKDNLKIVGXAU-UHFFFAOYSA-L.