Nedaplatin

Description: Nedaplatin (NSC-375101D) is a derivative of cisplatin and DNA damage agent for tumor colony forming units (IC50: 94 µM). Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucleophilic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death. Target: DNA/RNA Synthesis. Smiles: N.N.[Pt++].[O-]CC([O-])=O. References: Alberts DS, et al. Cancer Chemother Pharmacol, 1997, 39(6), 493-497.