Nedaplatin

Nedaplatin is a derivative of cisplatin (Cay-13119) with anticancer activity. Nedaplatin undergoes spontaneous hydrolysis to form platinum complexes that cross-link DNA resulting in apoptosis and cell death. It inhibits the growth of human NUGC-4 gastric and KSE-1 esophageal squamous carcinoma cells (IC50s = 4.6 and 3.4 µM, respectively) and inhibits S to G2 and G2/M to G1 cell cycle progression. Nedaplatin (44 mg/kg) decreases tumor volume and increases survival in a Lewis lung carcinoma syngeneic mouse model. Nedaplatin (40 mg/kg) also decreases tumor volume in an HNC-3 head and neck cancer mouse xenograft model. It exhibits reduced nephrotoxicity in rats compared with cisplatin.Formal Name: (SP-4-3)-diammine[2-(hydroxy-kappaO)acetato(2-)-kappaO]-platinum. CAS Number: 95734-82-0. Synonyms: NSC 375101. Molecular Formula: C2H8N2O3Pt. Formula Weight: 303.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: *soluble. SMILES: [NH3][Pt+2]([O-]C1=O)([O-]C1)[NH3]. InChi Code: InChI=1S/C2H3O3.2H3N.Pt/c3-1-2(4)5,,,/h1H2,(H,4,5),2*1H3,/q-1,,,+2/p-1. InChi Key: GYAVMUDJCHAASE-UHFFFAOYSA-M.