Necrosulfonamide

Item number	Size	Manual	Delivery time	Price
TGM-T6904-5mg	5 mg	-	7 - 10 business days*	52.00€
TGM-T6904-1mL	1 ml	-	7 - 10 business days*	52.00€
TGM-T6904-10mg	10 mg	-	7 - 10 business days*	67.00€
TGM-T6904-25mg	25 mg	-	7 - 10 business days*	140.00€
TGM-T6904-50mg	50 mg	-	7 - 10 business days*	220.00€
TGM-T6904-100mg	100 mg	-	7 - 10 business days*	387.00€
TGM-T6904-500mg	500 mg	-	7 - 10 business days*	924.00€

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Description: (E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks... more

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Product information "Necrosulfonamide"

Description: (E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Binds and inhibits gasdermin D. Inhibits pyroptosis. Target: MLK. Smiles: COc1nccnc1NS(=O)(=O)c1ccc(NC(=O)\C=C\c2ccc(s2)[N+]([O-])=O)cc1. References: Daohong Liao, et al. Med Chem Commun. 2014, 5, 333.

Keywords:	(E)-Necrosulfonamide
Supplier:	TargetMol
Supplier-Nr:	T6904

Properties

Application:	Necroptosis inhibitor, MLKL inhibitor
MW:	461.47 D
Formula:	C18H15N5O6S2

Database Information

CAS :	1360614-48-7\| Matching products
KEGG ID :	K08849 \| Matching products

Handling & Safety

Storage:	+4°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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