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Description: NDI-091143 is a potent, high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay), indirectly disrupting citrate binding via an unexpected mechanism of inhibition. Target: ATP Citrate Lyase. Smiles: COC(=O)c1cc(Cl)c(O)c(c1)S(=O)(=O)Nc1cc(c(F)cc1F)-c1ccccc1. References: Jia, Wei, Silvana, et al. An allosteric mechanism for potent inhibition of human ATP-citrate lyase[J]. Nature, 2019.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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