NBI 31772

NBI 31772 is a nonpeptide ligand that releases insulin-like growth factor-1 (IGF-1) from its binding protein (IGFBP, Kis = 1-24 nM for the six human subtypes of IGFBP). As the released IGF-1 is biologically active, NBI 31772 is used to assess the role of IGF-1 in cells and animals, including in neuron survival, skeletal muscle regeneration, and glucose homeostasis.Formal Name: 1-(3,4-dihydroxybenzoyl)-6,7-dihydroxy-3-isoquinolinecarboxylic acid. CAS Number: 374620-70-9. Molecular Formula: C17H11NO7. Formula Weight: 341.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 0.14 mg/ml. lambdamax: 258 nm. SMILES: OC1=C(O)C=C(C=C(C(O)=O)N=C2C(C3=CC=C(O)C(O)=C3)=O)C2=C1. InChi Code: InChI=1S/C17H11NO7/c19-11-2-1-7(4-12(11)20)16(23)15-9-6-14(22)13(21)5-8(9)3-10(18-15)17(24)25/h1-6,19-22H,(H,24,25). InChi Key: ZCMFEWUYBFMLIN-UHFFFAOYSA-N.