Naringin

Light yellow to beige powder. Soluble in DMSO (10mg/ml), DMF (20mg/ml) or ethanol (1mg/ml). Chemical. CAS: 10236-47-2. Formula: C27H32O14. MW: 580.54. Naringin is a citrus-derived flavonoid (bitter principal). It undergoes extensive metabolism in the liver. It has a broad panel of properties, including anti-inflammatory, antioxidant, anticancer, antidiabetic, cardioprotective, bone regenerative and neuroprotective activities. Naringin acts by modulating several signaling pathway targets, activity is primarily attributed to its anti-inflammatory (via inhibiting recruitment of cytokines and inflammatory transcription factors) and antioxidant (via scavenging of free radicals, bolstering of endogenous antioxidant defense system and metal ion chelation) effects. It increases the expression of neurotrophic factor in dopaminergic neurons, providing neuroprotection.