Naringenin

Naringenin is a citrus-derived flavonoid that inhibits CYP3A4 activity in human liver microsomes (IC50s = 139-188 µM). At 100 mg/kg/day, naringenin selectively inhibits the transcription of Smad3 and directly down-regulates TGF-beta1, significantly reducing lung metastasis in mice with bleomycin-induced pulmonary fibrosis. Naringenin demonstrates both lipid lowering and insulin-like properties in low-density lipoprotein (LDL) receptor-deficient mice fed a Western diet containing 1-3% naringenin by correcting VLDL overproduction, ameliorating hepatic steatosis, and attenuating dyslipidemia without affecting caloric intake or fat absorption.Formal Name: 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 67604-48-2. Synonyms: S-Dihydrogenistein, NSC 11855, NSC 34875, Salipurol. Molecular Formula: C15H12O5. Formula Weight: 272.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.50 mg/ml, DMSO: 5 mg/ml, Ethanol: 2.5 mg/ml. lambdamax: 213, 225, 289 nm. SMILES: OC(C=C1)=CC=C1C2CC(C3=C(O)C=C(O)C=C3O2)=O. InChi Code: InChI=1S/C15H12O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2. InChi Key: FTVWIRXFELQLPI-UHFFFAOYSA-N.