Naphthol AS-E Phosphate

Naphthol AS-E phosphate is an inhibitor of the protein-protein interaction between CREB and the KIX domain of CREB-binding protein (CBP, Ki = 50 µM). It also inhibits the binding of the transcription factor Myb to the KIX domains of p300 and CBP (IC50s = 30 and 43 µM, respectively). Naphthol AS-E phosphate inhibits CREB-dependent transcription in HEK293T cells (Ki = 10 µM). It also decreases the expression of Myb target genes and induces differentiation in HL-60, U937, and NB4 myeloid leukemia cells when used at a concentration of 5 µM. Naphthol AS-E phosphate inhibits proliferation of NCI-H1734 lung adenocarcinoma cells (IC50 = 6.89 µM).Formal Name: N-(4-chlorophenyl)-3-(phosphonooxy)-2-naphthalenecarboxamide. CAS Number: 18228-17-6. Synonyms: KG-501. Molecular Formula: C17H13ClNO5P. Formula Weight: 377.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 232, 273 nm. SMILES: O=C(C1=CC2=C(C=C1OP(O)(O)=O)C=CC=C2)NC3=CC=C(C=C3)Cl. InChi Code: InChI=1S/C17H13ClNO5P/c18-13-5-7-14(8-6-13)19-17(20)15-9-11-3-1-2-4-12(11)10-16(15)24-25(21,22)23/h1-10H,(H,19,20)(H2,21,22,23). InChi Key: RQAQWBFHPMSXKR-UHFFFAOYSA-N.