NAMPT inhibitor-linker 1

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Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
TGM-T18477-100mg	100 mg				7 - 10 business days*		-
TGM-T18477-500mg	500 mg				7 - 10 business days*		-

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Description: NAMPT inhibitor-linker 1, a drug-linker conjugate for ADC, integrates an NAMPT... more

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Product information "NAMPT inhibitor-linker 1"

Description: NAMPT inhibitor-linker 1, a drug-linker conjugate for ADC, integrates an NAMPT inhibitor (as a payload) with a linker. In the formulation of ADC-3, it pairs with an anti-c-Kit monoclonal antibody, demonstrating strong efficacy against c-Kit expressing cell lines, specifically GIST-T1 and NCI-H526, where it exhibits IC50 values of <3 pM and 9 pM, respectively. Target: Others, Drug-Linker Conjugates for ADC. Smiles: Fc1cc(NC(=O)[C@H]2C[C@@H]2c2cccnc2)ccc1CNC(=O)c1ccc(cc1)N1CCN(CC1)C(=O)CCOCCN1C(=O)C=CC1=O. References: Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28,9(8):838-842.

Supplier:	TargetMol
Supplier-Nr:	T18477

Properties

Application:	NAMPT inhibitor
MW:	668.71 D
Formula:	C36H37FN6O6

Database Information

CAS :	2241019-57-6\| Matching products
KEGG ID :	K03462 \| Matching products

Handling & Safety

Storage:	+4°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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