Nampt-IN-1

Nampt-IN-1 is a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt, IC50 = 3.1 nM). It is selective for Nampt over a panel of greater than 100 human kinases at 1 µM. Nampt-IN-1 inhibits NAD+ formation in and proliferation of HCT116 cells (IC50s = 1.8 and 8.9 nM, respectively). It inhibits cell growth in a panel of cancer cell lines (IC50s = + formation in an A2780 ovarian carcinoma mouse xenograft model (ED50 = 2 mg/kg).Formal Name: 2-hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-isoquinolinyl]-1-propanesulfonamide. CAS Number: 1698878-14-6. Synonyms: LSN3154567, Nicotinamide Phosphoribosyltransferase-IN-1. Molecular Formula: C20H25N3O5S. Formula Weight: 419.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: O=C(N1CCC(C=C(NS(CC(C)(O)C)(=O)=O)C=C2)=C2C1)COC3=CC=CN=C3. InChi Code: InChI=1S/C20H25N3O5S/c1-20(2,25)14-29(26,27)22-17-6-5-16-12-23(9-7-15(16)10-17)19(24)13-28-18-4-3-8-21-11-18/h3-6,8,10-11,22,25H,7,9,12-14H2,1-2H3. InChi Key: QHHSCLARESIWBH-UHFFFAOYSA-N.