Nafamostat (mesylate)

Nafamostat is a serine protease inhibitor that is capable of inhibiting trypsin (a digestive system protease, Ki = 15 nM), tryptase (a mast cell protease, Ki = 95.3 pM), and additional proteases in the coagulation cascade including thrombin (Ki = 0.84 µM). In a mouse model of allergic asthma, a dose of 300 mg/kg nafamostat mesylate has been shown to inhibit serine proteolytic activity, to decrease circulating levels of eosinophils and lymphocytes in bronchoalveolar lavage fluid, and to reduce interleukin-13 and eotaxin production associated with antigen-induced airway eosinophilia and goblet cell hyperplasia.Formal Name: 4-[(aminoiminomethyl)amino]-benzoic acid, 6-(aminoiminomethyl)-2-naphthalenyl ester, dimethanesulfonate. CAS Number: 82956-11-4. Synonyms: Coahibitor, FUT 175, Nafamastat. Molecular Formula: C19H17N5O2 . 2CH3SO3H. Formula Weight: 539.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 243 nm. SMILES: NC(C1=CC=C2C(C=CC(OC(C3=CC=C(NC(N)=N)C=C3)=O)=C2)=C1)=N.CS(=O)(O)=O.CS(=O)(O)=O. InChi Code: InChI=1S/C19H17N5O2.2CH4O3S/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23,2*1-5(2,3)4/h1-10H,(H3,20,21)(H4,22,23,24),2*1H3,(H,2,3,4). InChi Key: SRXKIZXIRHMPFW-UHFFFAOYSA-N.