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Description: N6F11 is a novel, selective and potent inducer of ferroptosis with anticancer and antitumour activity that promotes GPX4 degradation by binding to TRIM25 in cancer cells.N6F11 can be used to study pancreatic cancer. Target: GPX. Smiles: ClCC1=NC2=C(SC(=C2)C2=CC=C(Cl)C=C2)C(=O)N1. References: Li J, et al. Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer. Sci Transl Med. 2023,15(720):eadg3049.
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