N-Succinyl-5-aminoimidazole-4-carboxamide Ribose

A metabolite of Purine. Purine metabolism by adenylosuccinasedeficient. Since adenosine is a potent inhibitor of neuronal function, depressing the release of several excitatory transmitters and causing direct hyperpolarization of neurons, it was possible that the symptoms seen in adenylosuccinate lyase (ASase) deficient patients could reflect an interference of succinylpurines with neurotransmission. Melting Point: >230ºC (dec), Solubility: Water, Method for Determining Identity: Proton NMR (D2O) Spectroscopic and Mass Spectrometric Analysis, TLC Conditions: C18, Acetonitrile: Methanol = 9:1, Visualized with UV and AMCS, SIngle spot, Rf= 0.70, Sodium Content: 11.97%, Elemental Analysis: Calculated: %C: 37.33, %H: 3.86, %N: 13.39, Atmosphere: Inert Gas, Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4°C for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Hygroscopic. Store under inert atmosphere. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards:  All products should be handled by qualified personnel only, trained in laboratory procedures.