N-methyl Mesoporphyrin IX

N-methyl Mesoporphyrin IX is a transition state analog of porphyrin and an inhibitor of ferrochelatase. It inhibits ferrochelatase in mouse liver mitochondria in vitro and in vivo, leading to an accumulation of porphyrin in isolated liver mitochondria following administration of an intravenous dose of 80 nmol. N-methyl Mesoporphyrin IX has been used as a turn-on biosensor for target DNA sequences when used in complex with a G-quadruplex-forming sequence fused to a DNA sequence complementary to the target sequence. It has also been used to detect amyloid-beta (1-40) (Abeta40) fibrils in vitro and in live PC12 cells overexpressing Abeta. N-methyl Mesoporphyrin displays excitation/emission maxima of 399/610 nm, respectively.Formal Name: 8,13-diethyl-3,7,12,17,23-pentamethyl-21H,23H-porphine-2,18-dipropanoic acid. CAS Number: 142234-85-3. Molecular Formula: C35H40N4O4. Formula Weight: 580.7. Purity: >95% (mixture of isomers). Emission: 610 nm. Excitation: 399 nm. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.17 mg/ml, DMSO: 15 mg/ml. lambdamax: 299, 395, 564 nm. SMILES: CC1=C2[NH]C(/C=C(C(CCC(O)=O)=C3C)\[N]=C3/C=C4[N](C)/C(C(C)=C\4CC)=C\C5=[N]/C(C(C)=C5CC)=C\2)=C1CCC(O)=O. InChi Code: InChI=1S/C35H40N4O4/c1-8-22-18(3)26-14-27-19(4)24(10-12-34(40)41)29(36-27)15-30-25(11-13-35(42)43)20(5)28(38-30)16-33-23(9-2)21(6)32(39(33)7)17-31(22)37-26/h14-17,36H,8-13H2,1-7H3,(H,40,41)(H,42,43)/b26-14-,27-14-,28-16-,29-15-,30-15-,31-17-,32-17-,33-16-. InChi Key: XASXJWXLPCEQJN-UQOLDQHFSA-N.