N-Desmethyltamoxifen (hydrochloride)

N-Desmethyltamoxifen is an active metabolite of the estrogen receptor antagonist tamoxifen (Cay-13258, Cay-11629). It is formed from tamoxifen by the cytochrome P450 (CYP) isoforms CYP2D6, CYP2C19, CYP3A5, or CYP3A4. N-Desmethyltamoxifen is an inhibitor of PKC (IC50 = 8 µM for the rat enzyme). It decreases iron (III) chloride and ascorbate-induced increases in thiobarbituric acid reactive substances (TBARS) in rat liver microsomes (IC50 = 17.5 µM). N-Desmethyltamoxifen induces relaxation in isolated and washed rat aortic rings (pD2 = 9), an effect that can be blocked with the selective estrogen receptor degrader ICI 182780 (fulvestrant, Cay-10011269).Formal Name: 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N-methyl-ethanamine. CAS Number: 15917-65-4. Molecular Formula: C25H27NO . HCl. Formula Weight: 394.0. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly soluble: 1-10 mg/mL, Ethanol: Slightly soluble: 0.1-1mg/mL, PBS (pH 7.2): Slightly soluble: 0.1-1mg/mL. SMILES: CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(C=C3)OCCNC.Cl. InChi Code: InChI=1S/C25H27NO.ClH/c1-3-24(20-10-6-4-7-11-20)25(21-12-8-5-9-13-21)22-14-16-23(17-15-22)27-19-18-26-2,/h4-17,26H,3,18-19H2,1-2H3,1H/b25-24-,. InChi Key: GMLHJWZEYLTNJW-BJFQDICYSA-N.