N-desmethyl Rosiglitazone

N-desmethyl Rosiglitazone is a major metabolite of rosiglitazone (Cay-71740, Cay-71742, Cay-11884), a potent and selective PPARgamma ligand present in formulations that have been used to treat type 2 diabetes. Rosiglitazone is metabolized by the cytochrome P450 (CYP) isoform CYP2C8 to form N-desmethyl rosiglitazone.Formal Name: 5-[[4-[2-(2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione. CAS Number: 257892-31-2. Synonyms: SB-237216. Molecular Formula: C17H17N3O3S. Formula Weight: 343.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 34 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 242, 309 nm. SMILES: O=C(C(S1)CC(C=C2)=CC=C2OCCNC3=NC=CC=C3)NC1=O. InChi Code: InChI=1S/C17H17N3O3S/c21-16-14(24-17(22)20-16)11-12-4-6-13(7-5-12)23-10-9-19-15-3-1-2-8-18-15/h1-8,14H,9-11H2,(H,18,19)(H,20,21,22). InChi Key: ZJQTVMXUIGXRMR-UHFFFAOYSA-N.