This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Product information "N-Butyldeoxynojirimycin (hydrochloride)"
NB-DNJ is an iminosugar that inhibits UDP-glucose ceramide glucosyltransferase and beta-glucosidase 2 (IC50s = 32 and 81 µM, respectively, for the rat recombinant enzymes). It also increases the activity of wild-type acid beta-glucosidase, as well as the S364R, N370S, V15M, or M123T mutants, in COS-7 cells expressing the human enzymes when used at a concentration of 10 µM. NB-DNJ also inhibits HIV-1 and HIV-2 infection of peripheral blood mononuclear cells (PBMCs, IC50s = 282 and 211 µM, respectively). Formulations containing NB-DNJ have been used in the treatment of Gaucher disease, an inborn error of metabolism characterized as a lysosomal storage disorder resulting from substantial deficiency of beta-glucosidase.Formal Name: 1-butyl-2R-(hydroxymethyl)-3R,4R,5S-piperidinetriol, monohydrochloride. CAS Number: 210110-90-0. Synonyms: Miglustat, NB-DNJ. Molecular Formula: C10H21NO4 . HCl. Formula Weight: 255.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: OC[C@H]1N(CCCC)C[C@H](O)[C@@H](O)[C@@H]1O.Cl. InChi Code: InChI=1S/C10H21NO4.ClH/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12,/h7-10,12-15H,2-6H2,1H3,1H/t7-,8+,9-,10-,/m1./s1. InChi Key: QPAFAUYWVZMWPR-ZSOUGHPYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
More information