N-Acetyl-L-thyroxine

N-Acetyl-L-thyroxine is an acetylated derivative of L-thyroxine (Cay-14116). It only weakly binds to thyroxine-binding globulin (TBG) in isolated human serum with a relative binding affinity of 25 compared with L-thyroxine. N-Acetyl-L-thyroxine is also a potential impurity in commercial preparations of L-thyroxine.Formal Name: N-acetyl-O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine. CAS Number: 26041-51-0. Synonyms: N-acetyl-L-T4, N-Acetylthyroxine, N-acyl-L-T4. Molecular Formula: C17H13I4NO5. Formula Weight: 818.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 14 mg/mL, DMSO: 25 mg/mL, Ethanol: 20 mg/mL, PBS (pH 7.2): 0.2 mg/mL. lambdamax: 225 nm. SMILES: IC1=CC(C[C@@H](C(O)=O)NC(C)=O)=CC(I)=C1OC2=CC(I)=C(C(I)=C2)O. InChi Code: InChI=1S/C17H13I4NO5/c1-7(23)22-14(17(25)26)4-8-2-12(20)16(13(21)3-8)27-9-5-10(18)15(24)11(19)6-9/h2-3,5-6,14,24H,4H2,1H3,(H,22,23)(H,25,26)/t14-/m0/s1. InChi Key: NERGVJCCFAPEMR-AWEZNQCLSA-N.