N-acetyl Histamine

N-acetyl Histamine is a histamine metabolite that is formed via acetyl-CoA-dependent N-acetylation of histamine by AANATL7 in D. melanogaster, polyamine N-acetyltransferase in F. hepatica, and the arylalkylamine N-acetyltransferases aaNAT2 and aaNAT5b in A. aegypti. It selectively inhibits sweet-almond beta-glucosidase over yeast alpha-glucosidase in vitro (Kis = 0.035 and 20 mM, respectively). It also inhibits human glutaminyl cyclase (IC50 = 17 µM). N-acetyl Histamine has no effect on eosinophil activity and has been used as a negative control for histamine mediation of anaphylaxis.Formal Name: N-[2-(1H-imidazol-5-yl)ethyl]-acetamide. CAS Number: 673-49-4. Synonyms: Nomega-Acetylhistamine, NSC 66356. Molecular Formula: C7H11N3O. Formula Weight: 153.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 5 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(C)NCCC1=CNC=N1. InChi Code: InChI=1S/C7H11N3O/c1-6(11)9-3-2-7-4-8-5-10-7/h4-5H,2-3H2,1H3,(H,8,10)(H,9,11). InChi Key: XJWPISBUKWZALE-UHFFFAOYSA-N.