N-Acetyl-DL-penicillamine

Description: N-Acetyl-DL-penicillamine is a chelating agent.1,2,3It inhibits the binding of methyl mercury to isolated human erythrocytes by 50% and removes 50% of methyl mercury ions from methyl mercury-loaded blood cells when used at a concentration of 1 mM.1,2N-Acetyl-DL-penicillamine (3 mmol/kg per day, p.o.) reduces the biological half-life of mercury and decreases liver, kidney, brain, and blood mercury levels, as well as increases urinary excretion of mercury in a concentration-dependent manner, in mice when administered following injection of methyl mercuric chloride. It decreases mercuric chloride-induced mortality in mice when administered orally at a dose of 1.6 mmol/kg.3N-Acetyl-DL-penicillamine is also an analog of SNAP that does not generate nitric oxide and has been used as a negative control in experiments using SNAP.4,5. Target: Others. Smiles: CC(=O)NC(C(O)=O)C(C)(C)S. References: Aaseth, J.Mobilization of methyl mercury in vivo and in vitro using N-acetyl-DL-penicillamine and other complexing agentsActa Pharm. Toxicol. (Copenh.)39(3)289-301(1976)