N-acetyl-5-Aminosalicylic Acid
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: N-acetyl-5-Aminosalicylic acid is a metabolite of the anti-inflammatory agent... more
Product information "N-acetyl-5-Aminosalicylic Acid"
Description: N-acetyl-5-Aminosalicylic acid is a metabolite of the anti-inflammatory agent 5-aminosalicylic acid and its prodrug form, sulfasalazine . It is formed in the liver, intestinal lumen, and colonic epithelial cells via N-acetyltransferases. It reduces IFN-gamma binding to colonic epithelial cells by 24% when used at a concentration of 10 mM. N-acetyl-5-Aminosalicylic acid (100 µM) scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay and inhibits base hydroxylation in DNA stimulated by hydroxy radicals. Unlike sulfasalazine, N-acetyl-5-aminosalicylic acid does not inhibit 15-hydroxy prostaglandin dehydrogenase (PGDH). Urinary levels of N-acetyl-5-aminosalicylic acid have been used as a marker of 5-ASA adherence in patients with inflammatory bowel disease. Target: Others. Smiles: CC(=O)Nc1ccc(O)c(c1)C(O)=O
| Supplier: | TargetMol |
| Supplier-Nr: | T35708 |
Properties
| MW: | 195.17 D |
| Formula: | C9H9NO4 |
Database Information
| CAS : | 51-59-2| Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H319 |
| P Phrases: | P264, P270, P280, P301+310, P305+351+338, P330, P337+313, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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