Mycophenolic acid

White to off-white solid. Soluble in DMSO, methanol or ethanol. Insoluble in water. Antibiotic, Shows antiviral, antifungal and antitumor properties, Immunosuppressive drug used to prevent rejection in organ transplantation, rheumatoid arthritis, and psoriasis, Potent reversible inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH), leading to depletion of GMP and interruption of the de novo synthesis of purine nucleotides necessary for B and T lymphocyte proliferation, Inhibits the type II IMPDH isoform (IMPDH-2) 5-fold more potently compared to type I isoform, Inhibits RNA and DNA synthesis, Inducible nitric oxide synthase (iNOS/NOS II) inhibitor, Apoptosis and necrosis inducer, Novel type of inhibitor against RNA guanylyltransferases, Inhibits TNF-alpha-stimulated MAPK/NF-kappaB and ROS generation.