Mycophenolate Mofetil-d4

Mycophenolate mofetil-d4 is intended for use as an internal standard for the quantification of mycophenolate mofetil (Cay-13988) by GC- or LC-MS. Mycophenolate mofetil is a prodrug form of mycophenolic acid (Cay-21716). It is converted to mycophenolic acid via carboxylesterase 1 (CES1) and CES2. Mycophenolate mofetil (1 and 10 µg/ml) inhibits thymidine incorporation in primary rat aortic smooth muscle cells. In vivo, mycophenolate mofetil (12.5 mg/kg) increases the duration of transplant motor activity in a rabbit model of retroperitoneal heterotopic heart transplantation. It eliminates formation of microbleeds and hemorrhages in the cerebrum of stroke-prone spontaneously hypertensive rats when administered at a dose of 25 mg/kg. Mycophenolate mofetil (60 mg/kg) also lowers mean arterial pressure (MAP) and reduces urinary albumin excretion and glomerulosclerosis, markers of renal damage, in a mouse model of systemic lupus erythematosus (SLE).Formal Name: 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4E-hexenoic acid, 2-(4-morpholinyl)ethyl-1,1,2,2-d4 ester. CAS Number: 1132748-21-0. Synonyms: MMF-d4. Molecular Formula: C23H27D4NO7. Formula Weight: 437.5. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMF: 14 mg/ml, DMSO: 10 mg/ml, Ethanol: 1.4 mg/ml. SMILES: O=C(OC1)C2=C1C(C)=C(OC)C(C/C=C(C)/CCC(OC([2H])([2H])C([2H])([2H])N3CCOCC3)=O)=C2O. InChi Code: InChI=1S/C23H31NO7/c1-15(5-7-19(25)30-13-10-24-8-11-29-12-9-24)4-6-17-21(26)20-18(14-31-23(20)27)16(2)22(17)28-3/h4,26H,5-14H2,1-3H3/b15-4+/i10D2,13D2. InChi Key: RTGDFNSFWBGLEC-GWLAYVNQSA-N.