mTOR inhibitor-8

Description: mTOR inhibitor-8 is a potent mTOR inhibitor and autophagy inducer with antiviral and antitumor activity. mTOR inhibitor-8 inhibits the growth of A549 cells, which can be used to study non-small cell lung cancer. Target: mTOR, Autophagy. Smiles: COc1ccc(cc1)C1CC(=NN1c1nc(cs1)-c1ccncc1)c1ccc(Cl)cc1. References: ZhaoMin Lin, et al. Discovery of new fluorescent thiazole-pyrazoline derivatives as autophagy inducers by inhibiting mTOR activity in A549 human lung cancer cells. Cell Death Dis. 2020 Jul 20,11(7):551.