MST-312

MST-312 is a telomerase inhibitor (IC50 = 0.67 µM in a TRAP assay). It is selective for telomerase over DNA polymerase when used at concentrations up to 3 µM. MST312 inhibits growth of U937 cells via telomere shortening (GI50 = 1.7 µM). It reduces cell number and expression of the proliferation marker MIB-1 as well as increases DNA damage in primary pediatric ependymoma tumor cells. MST-312 decreases survival of H460 and H1299 non-small cell lung cancer (NSCLC) cells in a dose-dependent manner with a greater effect on the aldehyde dehydrogenase positive (ALDH+) cancer stem cell population. In vivo, MST-312 (40 mg/kg) reduces tumor size by 70% in an H460 mouse xenograft model. MST-312 also inhibits replication of herpes simplex virus 2 (HSV-2) and a clinical isolate of HSV-1 and decreases accumulation of early and late viral proteins in HEp-2 cells infected with HSV-1.Formal Name: N,N'-1,3-phenylenebis[2,3-dihydroxy-benzamide. CAS Number: 368449-04-1. Synonyms: Telomerase Inhibitor IX. Molecular Formula: C20H16N2O6. Formula Weight: 380.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:40): 0.025 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 213, 274 nm. SMILES: OC1=C(O)C(C(NC2=CC=CC(NC(C3=C(O)C(O)=CC=C3)=O)=C2)=O)=CC=C1. InChi Code: InChI=1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28). InChi Key: MIQUEZGHEJGPJB-UHFFFAOYSA-N.