MSAB

MSAB is an inhibitor of Wnt/beta-catenin signaling. It binds to beta-catenin and promotes its proteasomal degradation in HCT116 cells. MSAB (2-10 µM) selectively inhibits the proliferation of Wnt-dependent cancer cells over non-cancerous cells and Wnt-independent cancer cells. It reduces Wnt3a-induced increases in beta-catenin levels in a reporter assay using HEK293T cells. MSAB decreases the expression of the Wnt target genes AXIN2, MYC, CCND1, and BMP4 in a concentration-dependent manner in HCT116 cells. It reduces tumor growth and increases intratumoral apoptosis in Wnt-dependent HCT116, HT115, and H23 mouse xenograft models when administered at doses of 10 and 20 mg/kg.Formal Name: 3-[[(4-methylphenyl)sulfonyl]amino]-benzoic acid, methyl ester. CAS Number: 173436-66-3. Molecular Formula: C15H15NO4S. Formula Weight: 305.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 50 mg/ml, DMSO: 25 mg/ml, Ethanol: 10 mg/ml. lambdamax: 214 nm. SMILES: O=C(C1=CC(NS(=O)(C2=CC=C(C)C=C2)=O)=CC=C1)OC. InChi Code: InChI=1S/C15H15NO4S/c1-11-6-8-14(9-7-11)21(18,19)16-13-5-3-4-12(10-13)15(17)20-2/h3-10,16H,1-2H3. InChi Key: CVKBYFCJQSPBOI-UHFFFAOYSA-N.